Animal gut microbiomes play important roles in the health, diseases, and production of animal hosts.The volume of animal gut metagenomic data, including both 16S amplicon and metagenomic sequencing data, has been increasing exponentially in recent years, making it increasingly difficult for researchers to query, retrieve, and reanalyze experimental
Glucocorticoids remain the basis for treatment of myasthenia gravis in the era of targeted therapies
Myasthenia gravis Balloons Mini Foil (MG) treatment has entered an era of targeted therapies.Different targeted therapies take effect in various aspects of pathogenic mechanisms in MG.For a steady long-term control of MG symptoms, immunotherapies that reduce the production of pathogenic autoantibodies should be used.The glucocorticosteroid acts on
Activities of civic organizations in the field of protection of prisoners and rehabilitated persons in the soviet period legal assessment of russian crimes in Ukraine
Purpose.The purpose of the publication is to reveal the degree of involvement of public institutions in the protection of the rights of prisoners and rehabilitated persons in the Ukrainian SSR in the 1960s-1980s.Methods.The methodological basis of the research was a set of principles of historicism, objectivity, as well as general scientific, speci
IL-4 inhibits regulatory T cells differentiation by HDAC9-mediated epigenetic regulation
Abstract Regulatory T cells play a crucial role in orchestrating immune response and maintaining immune tolerance, and the expression of the Foxp3 gene is indispensable to the differentiation of regulatory T cells.IL-4 shows strong inhibitory effects on Foxp3 expression and regulatory T cells differentiation, but the detailed mechanisms are still u